ANTIOXIDANT SYSTEM IN THE PATHOGENESIS OF TUMOR DISEASES (BY THE EXAMPLE OF FIBROIDS AND UTERINE CANCER)

FIRMAN A.A, EFREMOV A.V, UZAKOV O.J.

Key words:

UTERINE CANCER, UTERINE FIBROIDS, ANTIOXIDANTS, B-CAROTENE, RETINOL, A-TOCOPHEROL

Abstract:

The aim of the study was to study the activity of the antioxidant system of the body in cancer patients, based on the content of fat-soluble antioxidants. 436 women were examined: 101 patients diagnosed with uterine fibroids; 290 women with uterine body cancer and 45 healthy women as controls. The content of b-carotene, retinol and a-tocopherol in blood serum was analyzed. It has been shown that in uterine cancer, unlike uterine fibroids, there is a more pronounced inhibition of the antioxidant system activity, expressed in a significant decrease in the levels of beta-carotene, retinol and a-tocopherol in the blood.

Conclusion: the inhibition of the antioxidant system activity in the mechanisms of development of tumor growth is beyond doubt.